Research Fellow/Scientist I, Research
Biogen is a pioneer in developing therapeutics for a wide range of challenging neurological disorders. Our cross-functional team provides a unique opportunity to leverage new understanding of microglial biology in the context of neuroinflammation and neurorepair to develop therapeutics that will transform the lives of patients living with debilitating neurodegenerative diseases.
About This Role
The Microglia and Neuroimmunology group at Biogen is seeking a highly motivated scientist to join our highly matrixed, multi-disciplinary initiative focused on the discovery of novel therapeutics for diseases with microglial pathology. The Research Fellow role at Biogen is an 18-month position designed to provide a unique opportunity for scientists to gain exposure to drug discovery and development and train in an industry research setting.
What You'll Do
As the Reserach Fellow, you are expected to lead, design, and execute an independent research project aimed at validating pro-reparative and pro-inflammatory microglial targets in the context of multiple therapeutic areas (AD, PD, ophthalmology, MSs and other neurodegenerative diseases).
The work will be expected to support new target identification, active drug discovery programs, and advance our understanding of microglia biology. The individual is expected to work independently and collaboratively in a cross-functional environment, drawing on deep and current knowledge of literature. The work will involve a wide array of in vitro, in vivo, and analytical techniques using cellular and molecular approaches, and is expected to advance projects towards clinical development.
Responsibilities
- Develop creative and innovative research plans to address key questions in microglial pathology and unveil disease relevant phenotypes
- Design and conduct in vitro and in vivo experiments in collaboration with team members
- Prepare, review, and deliver scientific presentations for internal and external use
- Build collaborations across the Research organization at Biogen and become a key member of a cross-research unit initiative focused on microglia biology
- Keep abreast of state-of-the-art technologies in the field
- Write reports, manuscripts, and generate data packages supporting model development and drug candidate advancement
Required Skills:
- PhD in Neuroscience or related field, and 0-2 years of postdoctoral experience
- Excellent technical skills
- Hands-on experience and expertise with undifferentiated iPSC culture and maintenance
- Experience differentiating and analyzing iPSC lines using quality control assays such as flow cytometry and immunocytochemistry
- Expertise in the execution and development of in vitro differentiation of iPSC into microglia
- A strong background in microglial biology, glial biology, phagocytosis, or neuroinflammation
- A successful track record of first author peer-reviewed publications
Preferred experience desired
- A successful track record of first author peer-reviewed publications
- Postdoc experience is preferred but not required
- Ophthalmology skills including intravitreal or subretinal injection OR
- Experience with myeloid/innate immune/microglial cell biology and functions such as neuroinflammation or phagocytosis and clearance
Why Biogen?
Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.
All your information will be kept confidential according to EEO guidelines.