Lab Manager / Research Assistant in Cardiovascular Research

We are seeking bright and highly motivated individual interested in developing skills and experience in biomedical and translational research as a lab manager or research technician at the Massachusetts General Hospital Cardiovascular Research Center and Harvard Medical School in the laboratory of Paul B. Yu, M.D., Ph.D.  The laboratory is dedicated to pursuing a deep cellular and molecular understanding of how dysregulated signaling regulates cell survival and differentiation in congenital and acquired vascular, metabolic, and musculoskeletal diseases. 

The lab is dedicated to understanding of intercellular signaling is interpreted in specific contexts to modify wound-healing, inflammation, and regeneration to yield productive or maladaptive tissue remodeling.   We utilize novel animal models of disease, chemical probes and reporter systems, as well as computational biology and bioinformatic techniques for analyzing large datasets from human clinical databases. Our work has recently led to novel treatments and diagnostic tests that have entered clinical testing.  The candidate will be trained in basic science and translational study methods, and potentially work with patients in the context of 1-3 pilot clinical studies.  Our work lies at the nexus of progenitor cell biology, chemical biology, cardiovascular physiology, and experimental pharmacology.

We welcome applications from intellectually curious individuals with an interest in developing their skills towards careers in Health Sciences, Research, or Drug Development.  Recent trainees have followed their work in the laboratory with subsequent Medical School and Clinical training (M.D. and M.D./Ph.D. programs), Graduate School (Ph.D. programs), Medical and Research Faculty Positions, and Biotech and Pharma Industry Positions.

Lab manager candidates are expected to have substantial prior experience in a wet lab research environment and will be responsible for overseeing activities related to compliance with institutional review board, biosafety and animal safety protocols, managing research supplies and stocks, animal husbandry, documentation, as well as contracts, laboratory billing and accounts. Lab managers will manage relationships with outside vendors, collaborating labs and institutions, Lab managers will also be expected to manage a portfolio of scientific projects in additional to these management responsibilities.

Research assistant candidates are expected to be able to design, perform and analyze in vitro and in vivo experiments using tools of molecular and cellular biology, collect and analyze clinical data from clinical databases and electronic health records, bioinformatics and statistics, animal models, and animal physiology in order to address fundamental mechanistic questions related to health and disease-related physiology.

All team members will work with a diverse and experienced team of PhD and MD trained scientists, and will receive training in responsible conduct of research and animal ethics. Team members will be expected to present their findings in local and international scientific meetings, and to contribute as co-authors for publications during their tenure. Previous members have published in journals including Science Translational Medicine, Nature Medicine, American Journal of Respiratory and Critical Care Medicine, Nature Chemical Biology, and Blood Journal.

Salary will be determined based on the role, combined with prior experience and qualifications.

A link to our published work: https://www.ncbi.nlm.nih.gov/myncbi/18S43cb7kFx/bibliography/public/

A recent undergraduate degree in Biological Sciences, Chemistry or Physics

Excellent written and verbal communication skills in English

Some experience with tissue culture, and molecular biology is preferred.

Excellent organizational skills

Interested applicants should send a cover letter, curriculum vitae and the names and contact information for 2 references through Handshake or directly to signaling@gmx.com.