Research Technician II

If interested in this opportunity, please visit www.mghcareers.org and apply for JOB ID# 3198047

Under general direction of PI or Lab Manager/Director, the Research Lab Technician II, performs or assists in a broad range of technical research activities and procedures; evaluates conclusions and has limited latitude to modify or devise methods and techniques as necessary to achieve desired results. The research project is particularly focused on developing novel cell and immunotherapeutic strategies for tolerance induction in allogenic transplantation and autoimmune conditions with special emphasis on new generations of chimeric antigen receptor T cell (also known as CAR T cells) therapy. The Research Lab Technician II is also responsible for some administrative elements of the research laboratory. This includes collection of and accurate recording of procedures and results, maintenance of databases used in the lab, ordering necessary reagents to conduct experiments, and participation in joint upkeep of the lab. Will be responsible for the collection and analyze of data using statistical methodology; may use computer programming to assist in data analysis.

The incumbent needs to have an understanding of the theory and scientific principles involved for the research project assigned to as well as good verbal and written communication skills. Must be able to work well as being part of a team. Should be capable of working very independently and display initiative to introduce innovations to the research study. Strong organizational and communication skills. Ability to lift boxes 20 pounds or greater. Sound interpersonal skills.

SPECIFIC DUTIES AND RESPONSIBILITIES:  

Carries out a wide range of moderate to complex lab techniques. in molecular techniques such as cell transfection and transduction, advanced flowcytometry skills, sequencing, with knowledge of advanced immunology, and synthetic biology skills including mammalian cell culture-based assays, flow cytometry, IHC, fluorescence microscopy, Western blot, PCR, ELISA and working with in vivo murine models. 

Executes protocols of non-routine experiments. Under the direction of the PI or designee, may assist with determining the most suitable methodology, with perform basic design and modification of protocols and with developing modifications of existing assay techniques, experimental protocols, or new procedures. 

Collects and records study data. Synthesizes and interprets information obtained from graphs, charts, laboratory experiments, statistical summaries, and other data collection methods. Interprets results develop new investigative techniques and/or to determine the most appropriate direction of research. Synthesis may involve use of computer programs as well as data entry into databases. Order animals, supplies and materials and maintain material inventory and cell inventory.

Collaborates with supervisor in writing and editing material for publication and may appear as secondary author on publications.

Notifies and seeks assistance from senior lab personnel or supervisor for any questions, unusual experimental conditions or results or needed training.

Maintains a lab notebook with experimental records. Prepares written reports on status of research, determination of technical procedures, sequence of operations, including statistical and graphic summaries of findings and possible conclusions for lab meetings.  

May operate and maintain moderate to complex lab equipment such as spectrophotometer, electron microscope, scintillation center, ultra-centrifuges and other scientific equipment related to research activity.

Participates in the upkeep of the lab; this includes keeping both direct and general workspaces clean and tidy and helping maintain an overall safe and clean environment. May perform, or refer as needed, routine maintenance of lab equipment to include cleaning and replacing of parts. Report equipment malfunctions and needs to management.

Works safely within the lab environment and in performing work duties. Wears personal protective equipment as required.

Performs independent literature searches. 

Provide functional guidance and assistance to lower-level technical personnel. May orient or teach moderately difficult to complex lab techniques to students and research personnel.

Attends and may make presentations at lab meetings and journal clubs.

Performs additional/miscellaneous duties assigned by Investigator.

 

 

QUALIFICATIONS:    

B.S/B.A. in biological or physical sciences.

Minimum of 1-year related research experience needed. Experience must include: documenting contributions to scientific presentations, and publications, training and experience in cell culture and immunohistochemistry, training in work with laboratory animals and experience in data analysis, and experimental design. 

SKILLS/ ABILITIES/ COMPETENCIES REQUIRED:    

Understanding of research techniques, procedures and equipment with applicable skills to facilitate performing the work of this position.

Self-motivated and able to work independently.

Functions with speed, precision, and an understanding of theory behind tests and procedures.

Must be able to work safely and properly use protective equipment.

Ability to prioritize tasks and set deadlines.

Ability to work carefully, accurately, and consistently with instruction or protocol.

Strong written and verbal communication skills along with the ability to effectively communicate technical information to staff.

Sound interpersonal skills.

Ability to identify problems and develop solutions.

Interest in translational research with the possibility of clinical trial administration in the future.

Proficiency in Word, PowerPoint and Internet searches is required.

Is knowledgeable and compliant in all hospital, State and Federal regulatory requirements, including hospital policy and procedures (where applicable to the performance of the job), Joint Commission on Accreditation of Healthcare Organizations (JCAHO), and Health Insurance Portability and Accountability Act of 1996 (HIPAA).

WORKING CONDITIONS:              

Duties will be performed in a research laboratory. This setting may create contact or exposure to one or more of the following: chemicals, fluids, sharp instruments and other supplies and equipment consistent with a research lab. Contact or exposure may be airborne or physical. 

Work will be conducted over a forty-hour workweek, but actual schedule can be flexible.

SUPERVISORY RESPONSIBILITY:  

None

FISCAL RESPONSIBILITY:               

Prudent use of hospital resources and cost-effective ordering of supplies.