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Technical Research Assistant I DOM Channing Bayer Pulmonary Drug Discovery (PDD) Laboratory

Primary Location MA-Boston-BWH Longwood Medical Area
Work Locations BWH Longwood Medical Area 75 Francis Street Boston 02115
Job Technician/Technologist/Scientist
Organization Brigham & Women's Hospital(BWH)
Schedule Full-time
Standard Hours 40
Shift Day Job
Employee Status Regular
Recruiting Department BWH Department Of Medicine
Job Posting May 17, 2022

The Partners/Bayer Pulmonary Drug Discovery (PDD) Laboratory utilizes in vitro and in vivo models to identify molecular targets related to chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD), to determine the mode of action of the targets, and to identify and test potential therapeutic modalities for COPD and ILD. The PDD Laboratory RA Junior actively participants in experimental research related to these goals and has the capability to present his/her lab work. He/she works with minimal supervision from the supervisor, and performs non-routine, highly specialized experiments. Will need to troubleshoot instrument or protocol failures, and is responsible for managing supply inventory of designated task areas. 

1)  Participate in molecular and cellular biology experiments, including but not limited to: PCR, DNA and protein gel electrophoresis, Western blots, RNA preps, quantitative real-time PCR, mammalian cell (tissue) culture, transfect and infect cells with expression vectors, CRISPR - cas9 delivery in primary cells, organoid cultures, and precision cut lung slice studies.
2)  Work with murine models of lung disease relevant to molecular targets of interest, including murine colony maintenance, genotype confirmation of gene-targeted mice, exposure studies, and cell and molecular studies based on samples from murine models. 
3)  Execute experimental studies to validate and understand the biology of identified molecular targets and new mechanisms and maintain complete daily records of methodologies and test results in an electronic laboratory notebook.
4)  Work with other laboratory staff, including Bayer scientists, to drive the process of drug development for validated mechanisms and targets.
5)  Keep record of studies, analyze data sets, prepare and present results at PDD Laboratory meetings, which may include the Bayer team in Germany.
6)  Communicate and interact with interdisciplinary project teams.
7)  Maintain equipment and supplies in a neat and orderly manner. 
8)  Submit and place orders for supplies, chemicals, and other reagents.
9)  All other duties as assigned.


1)  Quality of work and data produced – accuracy, attention to detail, raises questions promptly with Investigators about matters affecting data quality. Ability to independently follow protocols and troubleshoot procedures as required.
2)  Time management – meets deadlines, balances multiple projects at all times, plans with supervisors and other staff to work together to meet deadlines.
3)  Standards – knowledge of subject matter and continually striving to learn more about methods, and project design.
4)  Communication – professional, courteous, and accurate communication of progress or results to supervisors and principal investigators.
5)  Documentation – ability to provide thorough written and/or electronic documentation of all costs, protocols, weekly project status reports and laboratory project-tracking “bugs” and regularly review with principal investigators.

EEO Statement
BWH is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.