Intern, Drug Metabolism & Pharmacokinetics
At Biogen, our mission is clear - we are pioneers in neuroscience. Biogen discovers, develops, and delivers worldwide innovative therapies for people living with serious neurological and neurodegenerative diseases. Together, our employees create, commercialize, and manufacture transformative therapies for our patient population.
We at Biogen are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients who we serve. We are focused on strengthening our foundation to advance our overall Diversity, Equity and Inclusion (DE&I) strategy and, most importantly, ensure all our employees feel included.
As an intern or co-op at Biogen, you can expect to be placed on a real project, under the guidance of experienced professionals and subject matter experts who are invested in your career and academic growth. We also ensure that you have plenty of opportunities to build your network, learn more about our organization through weekly lunch and learns led by leaders from across the company, and join us for several fun events.
Summary:
This application is for a 12-week internship role from June - August 2023. Resume review begins in January 2023.
Drug Metabolism & Pharmacokinetics (DMPK) Department is a dynamic department that supports the entire continuum of drug discovery and development at Biogen. DMPK leverages cut-edging technologies, deep subject matter expertise and broad scientific knowledge to deliver critical in vitro and in vivo DMPK data to support our drug discovery and development pipeline. Bioanalysis (BA) group, an integral part of DMPK, conducts studies to assess PK/PD characteristics of novel chemical entities/metabolites via rugged and sensitive LC-MS/MS-based assays. As a summer intern within BA group, you will explore various technologies to further improve our current quantitative assays for oligonucleotides. You will learn fundamentals of bioanalysis and mass spectrometry through collaborating with experienced scientists.
Position Description
Detailed description of role including but not limited to:
- Develop and optimize LC-MS/MS bioanalytical method for quantification of oligonucleotides, which includes literature search and rationale with-respect-to experimental designing, executing laboratory experiments, performing data analysis and interpretations.
- Explore and compare sample preparation techniques to process complex biological matrices, such as plasma, cerebrospinal fluid, and tissues.
- Under supervision, engage in troubleshooting and system suitability assessments for a variety of analytical instrumentation.
- Process data and summarize results.
- Report and present experimental results.
Example projects may include:
- Project 1: LC-MS-based method development for the quantification of oligonucleotides in plasma and tissue samples.
Qualifications:
- Basic analytical chemistry lab skills are required
- Understanding of common techniques used in bioanalytical research, including sample preparation, liquid chromatography and mass spectrometry
- Hands-on experience with biological sample preparation and LC-MS/MS analysis
- Good understanding of quantitative analysis theories • Strong communication and problem-solving skills
- Passionate about learning and taking new challenges
- Knowledge or experience in oligonucleoside bioanalysis is preferred but not required
To participate in the Biogen Internship Program, students must meet the following eligibility criteria:
- Legal authorization to work in the U.S.
- At least 18 years of age prior to the scheduled start date
- Be currently enrolled in an accredited college or university
Education:
Current MS or PhD students majored in Pharmaceutical Sciences, Biochemistry, Chemistry, or a related field.
Location:
Cambridge, MA