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Research Technician - Human Cancer Systems Immunology

The MGH Immunoprofiling laboratory is a translational research group focused on using cutting-edge genomics and microscopy to understand human cancer immunology. We are part of the Massachusetts General Hospital Cancer Center and Nir Hacohen’s lab at the Broad Institute. In recent years, immunotherapy has transformed cancer treatment, though only a subset of patients respond. Our primary objective is to develop tools to predict patient response to immunotherapy that we translate into clinical tests. At the same time, we seek to broaden our understanding of basic tumor immunology. Our approach is to use unbiased methodologies, including screens and single cell RNA sequencing of human cancer specimens, to identify clinically useful biomarkers. We also work extensively with novel ultrahigh-plex RNA imaging technologies. For more information, please see our most recent studies (Cell 2021; Nature Medicine 2022). 

Ideal candidates are interested in working at the interface of research and clinical medicine (e.g. recent college graduates considering MD and/or PhD training). We prioritize mentorship and seek to prepare our trainees for successful careers in biomedical research. Our recent technicians have gone on to top MD and MD/PhD programs. 

As critical members of the team, technicians contribute both intellectually and experimentally at the bench and in data analysis. Candidates must have at minimum a college degree in a STEM field and computational or wet lab experience. We have automated many of the tasks in our lab, so applicants must be very comfortable working with computers. Additionally, because we employ a team-based, interdisciplinary approach, applicants must have excellent communication skills and work well with others. Cancer biology, immunology, histology, and informatics are a plus, but can be learned on the job. Applications will be reviewed until job is filled.