Research Associate II, In Vivo for Hematology Research (26257)
From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.
We are seeking a motivated Research Associate II to join the in-vivo non-oncology Hematology Therapeutic Area team at BioMarin. The successful candidate will have a hands-on role in the development, optimization, and implementation of genetic models of hematological diseases. The ideal candidate will have extensive in vivo experience researching genetic non-malignant hematology disorders, particularly in the context of evaluating novel therapeutic approaches (including but not limited to biologics, small molecules, and gene therapies) and mode of action. In vivo responsibilities include administration of test articles, in-life blood collections, necropsies, as well as microscopic surgeries and in vivo imaging to conduct bleeding models in rodents. Experience with assays related to hemostasis is highly desired.
- Organize and maintain mouse colonies
- Assist in the design of in vivo model systems/proof of concept studies to assess efficacy of therapies targeting hematological diseases
- Perform in vivo experiments including but not limited to dosing (ip, iv, sc, po, ro, etc.), PK/PD studies, sample and tissue collections, and ex vivo assays.
- Recognize and adhere to IACUC standards of in vivo research
- Perform data recording and statistical analysis; Document all experimental procedures and data in electronic notebook
- Assist in writing IACUC protocols and study reports
- Proficiency with standard in vivo operations such as animal handling, anesthesia, in-life blood collections, and necropsies.
- Proficiency in the following routes of administration; tail vein i.v., i.p., s.c., p.o., and r.o.
- Familiarity with laboratory animal management software (Mosaic) and computer databases for IACUC protocol management (Cayuse) preferred.
- Basic understanding and knowledge of hematology with an emphasis on coagulation, thrombosis and hemostasis are highly desirable
- Hands-on experience with rodent in vivo and ex vivo models of hemostasis and bleeding is highly preferred
- Experience with in vivo imaging is a plus
- Ability to work independently as well as collaboratively in a dynamic environment
- Computer skills such as experience with Microsoft Word, Excel, PowerPoint, GraphPad Prism.
- Persons without in vivo experience need not to apply.
- 2+ years of experience with in-vivo studies
- Broad technical proficiency
- Ability to solve complex scientific and technical issues
- Excellent oral and written English communication skills, ability to prepare and present data in group settings
Bachelor’s degree and at least 4 years of experience; Master’s degree with at least 2 years of relevant experience
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.