Chemistry Undergraduate Summer Internship for students living in Boston, who receive Pell Grants
Company: Blueprint Medicines
At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.
This is the place where the extraordinary becomes reality, and you could be part of it. Patients are waiting. Are you ready to make the leap?
Website: https://www.blueprintmedicines.com/
JOB TITLE – Intern, Preformulations
Blueprint Medicines is seeking an intern to support preformulation and early drug product research on new chemical entities. This temporary position resides within the Formulations Sciences group of Technical Operations in the Non-clinical Development Sciences organization. The intern candidate will contribute to the execution of laboratory activities related to the transition of novel small molecule compounds from Discovery into Development in support of Blueprint Medicines’ pre- clinical programs. An ideal candidate will have a strong foundation in chemistry, and a keen interest in pharmaceutics/drug product development.
TYPICAL WORKING HOURS
Monday-Friday: 9-5 pm
40 hours/week
Program dates are expected to be May 28th - August 16th, with flexibility as needed.
SUMMER VACATION
July 1st - 5th (company shut down)
Additional vacation time can be discussed with supervisor
RESPONSIBILITIES
- Performing excipient screens for new chemical entities
- Performing physicochemical characterization of new chemical entities and preclinical formulations using: [XRPD, PLM, HPLC and dissolution.
- Preparing buffers and other solutions required for the laboratory
- Maintaining an accurate and timely lab notebook
In addition to assisting in routine preformulation laboratory analyses, the candidate will also be investigating and implementing the following individual project:
- Investigate nanoparticle suspension and develop formulation prototypes for screening.
- Assess the impact of enabled formulations on exposures for poorly soluble compounds, including targeted protein degraders.
- Determine in vivo exposure between conventional and enabled formulation, with lipidic chase dosing for targeted protein degraders.
- The candidate will coordinate with in-house animal care facility personnel to prepare formulations and interpret animal data to determine the impact of lipidic formulations on in vivo exposures.
Onsite expectations – 5 days/week
This internship will be a chance for you to learn many of the skills mentioned above.
DESIRED MAJORS/MINIMUM QUALIFICATIONS + SKILLS
Rising sophomore, junior or senior pursuing a degree in Chemistry or related field
YOUR INTERVIEW PROCESS
Our interview process will include 2-4 zoom interviews with members of the team you are interviewing to be a part of. We are seeking students who are eager to learn and grow! Preparation could include reviewing the Blueprint website, and being prepared to tell us why you are interested in our role and what you hope to learn from your internship experience. We are looking forward to speaking with you!
PAY RATE
$23-25/hour, based on class year
LOCATION
45 Sidney Street, Cambridge, MA 02139
Accessible via public transportation: Central Square Stop on the Red Line or Bus 1 and 47, Mass Ave/Sidney Street Stop.
REMOTE-WORK
It would be ideal for the candidate to work on-site in order to participate in program events, but a hybrid schedule will work as responsibilities can be done remotely. We will provide a laptop needed to perform work remotely or on-site.
CANDIDATE PREFERENCES
- Interest in Pharmaceutics, medicine, organic chemistry, drug development/formulation
- Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism
- Excellent interpersonal, organizational, verbal, and written communication skills, with the ability to work in a team environment
- Demonstrated ability to work independently and seek resources as necessary
Why Blueprint?
At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success. This is the place where the extraordinary becomes reality, and you could be part of it.
Patients are waiting. Are you ready to make the leap?